# 肠道菌减肥计划

Fat Gets Gut Bacteria Working against the Waistline

Think it’s your inability to resist cheesecake that’s making it tough to fit into your skinny genesjeans? Well, your bacteria may share some of the blame. Because a new study in mice shows that the responsive response of intestinal microbes to a high-fat diet ends up triggering the release of a hormone that makes mammals feel hungry, causing them to eat even more. The finding is served up in the journal Nature.

Previous work had has shown that the types of bacteria in the gut in diabetic or obese individuals are different from the bacteria in healthy people. But does these bacteria make a this bacterial makeup contribute to these disorders, ? Or is it just a side effect?

To unravel this mystery, researchers put mice on a high-fat diet. The animals experienced to built a buildup of a chemical called acetate, particularly in the large intestine.

That location points to gut bacteria, which can produce acetate, as a possible culprit. So the researchers wiped out the microbes using antibiotics or a simple saline wash. And acetate levels plummeted.

Okay, so the gut bacteria in fat-fed mice make acetate. What does acetate do? Well, it gets the involuntary part of the nerve nervous system, the parasympathetic nerve nervous system. , to put out the call to produce more insulin. Unfortunately, in this case, acetate also gets the parasympathetic nerve nervous system to stimulate the production of a hunger hormone called ghrelin. And the more fat fats an animal consumes, the more acetate it makes . - which means the more ghrelin it produces , and, of course, the more it eats. And bacteria make the whole sequence happen.

The researchers are now investigating , whether the same biochemical events happen in humans. If they do, it’s possible that obtaining a better assortment assortments of gut bacteria could help us control our weight. Of course, the best way to get those good bacteria is from a fecal transplant . - in which bacteria-rich feces come out of one person and into you. The very thought of which could help curb your appetite.

• Words worth to be remembered:
• serve up phr. 端上，提供，提出
• buildup n. 组织,组成,增强
• acetate n. 醋酸纤维（素）
• plummet n. 铅锤；坠子 v. 垂直落下；骤然下跌
• assortment n. 花色品种；混合物；分类
• curb n. 限制；路缘，路边 v. 控制，抑制
• ghrelinn n. 胃饥饿素（一种胃肠道激素）
• saline adj. 含鹽的，鹽的 n. 鹽湖；鹽溶液

## 譯文：

• “()”中的是我認爲正確的翻譯
• 黑體字是我認爲翻譯得好的部分

##### Chaochen Wang 王　超辰
###### Assistant Professor

All models are wrong, but some are useful.